Jean-Jacques Bourguignon Selected Research

phenylalanyl- leucyl- phenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamide

11/2018	Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia.
1/2017	RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.
8/2015	Neuropeptide FF receptors as novel targets for limbic seizure attenuation.
12/2013	Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors.
1/2006	RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.

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Jean-Jacques Bourguignon Research Topics

Disease

8	Hyperalgesia 09/2019 - 01/2006
5	Pain (Aches) 09/2019 - 01/2006
3	Neuralgia (Stump Neuralgia) 01/2022 - 05/2012
3	Hypersensitivity (Allergy) 01/2022 - 01/2017
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 01/2002
3	Inflammation (Inflammations) 04/2018 - 02/2003
2	Asthma (Bronchial Asthma) 01/2021 - 02/2003
2	Chronic Pain 03/2015 - 01/2006
1	Lung Neoplasms (Lung Cancer) 01/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022
1	Peripheral Nerve Injuries 01/2022
1	Atherosclerosis 01/2021
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2021
1	Neonatal Sepsis 01/2020
1	Sepsis (Septicemia) 01/2020
1	Cognitive Dysfunction 01/2020
1	Myalgia 04/2018
1	Pleurisy (Pleuritis) 04/2018
1	Seizures (Absence Seizure) 08/2015
1	Epilepsy (Aura) 08/2015
1	Hypertension (High Blood Pressure) 10/2014
1	Alzheimer Disease (Alzheimer's Disease) 07/2013
1	Neuroblastoma 07/2013
1	Neuroinflammatory Diseases 07/2013
1	Pancreatic Neoplasms (Pancreatic Cancer) 05/2012
1	Disease Progression 01/2012
1	Proteinuria 01/2012

Drug/Important Bio-Agent (IBA)

5	neuropeptide FF receptorIBA 11/2018 - 01/2006
5	Opioid Analgesics (Opioids)IBA 11/2018 - 01/2006
5	phenylalanyl- leucyl- phenylalanyl- glutaminyl- prolyl- glutaminyl- arginyl- phenylalaninamideIBA 11/2018 - 01/2006
3	LigandsIBA 01/2019 - 08/2015
2	Pharmaceutical PreparationsIBA 01/2022 - 01/2020
2	CytokinesIBA 01/2022 - 01/2002
2	MY 5445IBA 01/2022 - 09/2019
2	LipopolysaccharidesIBA 01/2022 - 01/2020
2	Sildenafil Citrate (Viagra)FDA Link 01/2022 - 09/2019
2	indole-3-guanylhydrazone hydrochlorideIBA 01/2020 - 04/2018
2	Analgesics (Analgesic Drugs)IBA 11/2018 - 01/2017
2	Opiate AlkaloidsIBA 11/2018 - 01/2017
2	Fentanyl (Sublimaze)FDA LinkGeneric 11/2018 - 01/2017
2	AmidesIBA 01/2017 - 12/2013
2	Peptides (Polypeptides)IBA 12/2013 - 07/2013
2	Phosphodiesterase 4 InhibitorsIBA 01/2012 - 02/2003
2	Cyclic AMP (AMP, Cyclic)IBA 01/2012 - 02/2003
1	Cisplatin (Platino)FDA LinkGeneric 01/2022
1	CoumarinsIBA 01/2022
1	diethylstilbestrol monophosphate (PDES)IBA 01/2022
1	vinpocetineIBA 01/2022
1	Theophylline (Theon)FDA LinkGeneric 01/2022
1	ibudilastIBA 01/2022
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2022
1	YM 976IBA 01/2022
1	9-(2-hydroxy-3-nonyl)adenine (EHNA)IBA 01/2022
1	EtazolateIBA 01/2022
1	zaprinastIBA 01/2022
1	RolipramIBA 01/2022
1	Milrinone (Primacor)FDA LinkGeneric 01/2022
1	Phosphodiesterase InhibitorsIBA 01/2022
1	NF-kappa B (NF-kB)IBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	2-aminobenzimidazoleIBA 01/2021
1	MitogensIBA 01/2021
1	Interleukin-6 (Interleukin 6)IBA 01/2021
1	Phosphodiesterase 5 InhibitorsIBA 09/2019
1	IsoenzymesIBA 09/2019
1	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 09/2019
1	NeurosteroidsIBA 01/2019
1	HydrazonesIBA 11/2018
1	DipeptidesIBA 11/2018
1	pimagedine (aminoguanidine)IBA 11/2018
1	AcidsIBA 04/2018
1	CarrageenanIBA 04/2018
1	Formaldehyde (Formol)FDA Link 04/2018
1	Acetic Acid (Vinegar)FDA LinkGeneric 04/2018
1	Anticonvulsants (Antiepileptic Drugs)IBA 08/2015
1	Pilocarpine (Ocusert)FDA LinkGeneric 08/2015
1	BIBP 3226IBA 08/2015
1	OrnithineIBA 03/2015
1	PeptidomimeticsIBA 03/2015
1	Guanabenz (BR 750)FDA Link 10/2014
1	Morphine (MS Contin)FDA LinkGeneric 12/2013
1	Amyloid (Amyloid Fibrils)IBA 07/2013
1	Metalloproteases (Metalloproteinases)IBA 07/2013
1	Neprilysin (Neutral Endopeptidase)IBA 07/2013
1	Proteins (Proteins, Gene)FDA Link 07/2013
1	Caspase 3 (Caspase-3)IBA 05/2012
1	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 01/2012
1	Cyclic NucleotidesIBA 01/2012
1	2- trifluoromethyl- 9- (2- fluorophenylmethyl)- N- methyladenineIBA 01/2012
1	Heroin (Diamorphine)IBA 01/2006

Therapy/Procedure

2	Analgesia 03/2015 - 12/2013
1	Therapeutics 01/2022